Purine metabolism-related genes and immunization in thyroid eye disease were validated using bioinformatics and machine learning

Abstract Thyroid eye disease (TED), an autoimmune inflammatory disorder affecting the orbit, exhibits a range of clinical manifestations.While the disease presentation can vary, cases that adhere to a prototypical pattern typically commence with mild symptoms that subsequently escalate in severity before entering a phase of stabilization.Notably, t

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Distinct motor impairments of dopamine D1 and D2 receptor knockout mice revealed by three types of motor behavior

Both D1R and D2R knock out (KO) mice of the major dopamine receptors show significant motor impairments.However, there are some discrepant reports, which may be due to the differences in genetic background and experimental procedures.In addition, only few studies directly compared the motor performance of D1R and D2R KO mice.In this paper, we exami

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Craniofacial ontogeny in Centrosaurus apertus

Centrosaurus apertus, a large bodied ceratopsid from the Late Cretaceous of North America, is one of the most common fossils recovered from the Belly River Group.This fossil record shows nitrile gloves in a bucket a wide diversity in morphology and size, with specimens ranging from putative juveniles to fully-grown individuals.The goal of this stud

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